Pharm Ingredients
Ascorbyl Glucoside AA2G Powder
Ascorbyl Glucoside AA2G Powder Manufacturers
Ascorbyl glucoside AA2G powder supplied by Kintainutri® is a highly stable, water-soluble derivative formed by combining Vitamin C (ascorbic acid) with glucose. As an excellent antioxidant and skin-conditioning agent, AA2G effectively scavenges free radicals and reduces DNA damage caused by UV radiation, while offering the advantages of low irritation and resistance to oxidation-induced discoloration.
Compared to standard Vitamin C, it is more stable and gentler in formulations, making it ideal for anti-aging and brightening products such as serums and creams; it is widely used as a key antioxidant and skin-conditioning agent in high-end cosmetics. Kintainutri®’s AA2G powder boasts a purity of over 98%, making it an ideal choice for cosmetic ingredient suppliers.
Contact us | Item | Specification | Test Method |
|---|---|---|
| Physical Control | ||
| Appearance | White Crystalline Powder | Visual |
| Odor | Characteristic | Organoleptic |
| Taste | Characteristic | Organoleptic |
| Content | 99% | HPLC |
| Loss on Drying | ≤5.0% | Gravimetric |
| Ash | ≤5.0% | Gravimetric |
| Particle size | 95% pass 80 mesh | Analytical Sieving |
| Allergens | None | ELISA |
| Chemical Control | ||
| Heavy metals | NMT 10ppm | ICP-MS |
| Arsenic | NMT 2ppm | AAS |
| Lead | NMT 2ppm | AAS |
| Cadmium | NMT 2ppm | AAS |
| Mercury | NMT 2ppm | ICP-MS |
| GMO Status | GMO Free | PCR |
| Microbiological Control | ||
| Total Plate Count | 10,000cfu/g Max | AOAC |
| Yeast & Mold | 1,000cfu/g Max | AOAC |
| E.Coli | Negative | AOAC |
| Salmonella | Negative | AOAC |
How To Make Ascorbyl Glucoside AA2G Powder?
Ascorbyl Glucoside AA2G Powder Benefits
Spot Reduction and Skin Brightening
As a potent reducing agent, ascorbyl glucoside AA2G powder reduces the dark melanin (quinone form) produced during melanogenesis into light-colored, reduced melanin (phenolic form), thereby directly fading existing pigmentation. Additionally, it inhibits tyrosinase activity to reduce the conversion of tyrosine into melanin and simultaneously reduces the intermediate product dopaquinone, effectively blocking melanin production at the source. Derivatives such as Ascorbyl Glucoside (AA2G) and 3-O-Ethyl Ascorbic Acid share this dual mechanism of action, making them suitable for use in skincare products designed for skin brightening, dark spot reduction, and post-sun exposure repair.
UVA-Induced Photoaging Inhibition
Ascorbic Acid 2-Glucoside exerts an antioxidant effect by scavenging ultraviolet-induced reactive oxygen species (ROS).In melanocytes, UVA irradiation triggers the formation of delayed cyclobutane pyrimidine dimers, known as “dark-state CPDs,” via a chemiexcitation pathway. This process persists for hours and plays a critical role in DNA damage and photoaging.
By significantly inhibiting ROS generation, ascorbyl glucoside AA2G powder blocks the free radical cascades mediated by nitric oxide synthase (NOS) and NADPH oxidase (NOX), thereby reducing the formation of dark-state CPDs at the source. Furthermore, as a premier grade of AA2G for skin applications, it inhibits melanogenesis, synergistically lowering the risk of UV-induced DNA damage and providing a scientific basis for the development of after-sun repair and nighttime skincare products.
Advanced Wound Healing
Ascorbyl glucoside AA2G powder significantly enhances the proliferation, migration, and angiogenic capabilities of bone marrow-derived mesenchymal stem cells (BMSCs) by activating the PI3K/AKT signaling pathway; simultaneously, it upregulates TET2 protein expression, promotes DNA hydroxymethylation (5-hmC) and demethylation processes, and maintains stem cell function. Through paracrine signaling, AA2G-pretreated BMSCs promote fibroblast (NIH-3T3) migration and collagen synthesis (upregulating MMP-3/9 and hydroxyproline) while enhancing the tube-forming ability of vascular endothelial cells.
In animal models, Ascorbic Acid 2-Glucoside-pretreated BMSCs significantly accelerate wound healing and increase neovascular density and collagen deposition, providing a scientific basis for the development of stem cell therapies and functional skincare ingredients aimed at promoting wound repair.
What Is Ascorbyl Glucoside AA2G Powder Used For？
Ascorbyl glucoside is a highly stable derivative synthesized from vitamin C (ascorbic acid) and glucose via enzymatic catalysis. As a water-soluble, non-irritating source of vitamin C, it exhibits excellent antioxidant properties and skin-conditioning functions in cosmetic formulations, making it widely used in skincare products such as ascorbyl glucoside serums, creams, lotions, and eye creams. This stability allows formulators to create elegant, long-shelf-life products without the need for complex packaging or low-pH adjustments that can cause skin irritation.
Ascorbyl Glucoside AA2G Powder Side Effects And Safety
Low skin permeability: As a highly polar (hydrophilic) molecule, in vitro permeation studies confirm its limited ability to penetrate the skin barrier; it acts primarily on the epidermal layer, with negligible systemic absorption.
Safe metabolic pathway: Trace amounts absorbed through the skin are naturally converted within the body into L-ascorbic acid (vitamin C) and glucose. Both are essential endogenous nutrients for the human body, posing no risk of harmful accumulation.
Toxicological data support:
| Irritation |
Non-irritating to the skin; mildly irritating to the eyes. |
| Sensitization |
No skin sensitization observed in Human Repeat Insult Patch Tests (HRIPT). |
| Genotoxicity |
Negative results in Ames tests, chromosomal aberration assays, etc.; no genotoxicity. |
Regulatory Status Of Ascorbyl Glucoside AA2G Powder
USA: The CIR Expert Panel has determined that AA2G is safe for use in cosmetics at current usage levels and concentrations.
EU: Not subject to any restrictions under Cosmetics Regulation (EC) No. 1223/2009.
China: Included in the Inventory of Existing Cosmetic Ingredients.
Where Can I Buy Ascorbyl Glucoside AA2G Powder?
Leveraging extensive industrial manufacturing experience and advanced enzymatic biocatalysis technology, Kintainutri® offers highly stable Ascorbyl Glucoside (AA2G) powder with a purity exceeding 98%.
We provide not only high-quality raw materials with excellent batch-to-batch consistency but also a comprehensive traceability system covering the entire process from source to finished product. Our team provides 24/7 support and delivers comprehensive regulatory documentation, including Certificates of Analysis (COAs), Safety Data Sheets (MSDSs), and complete technical data packages. We also offer expert formulation guidance and stability testing support tailored to the complex requirements of leading cosmetic manufacturers in Europe, the United States, and global markets. Kintainutri® is your trusted long-term B2B partner for bulk raw materials; contact us to request a free sample.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
FAQ
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What does ascorbyl glucoside AA2G powder do to your skin?
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Is ascorbyl glucoside powder the same as vitamin C?
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What not to use with ascorbyl glucoside AA2G powder?
Ascorbyl Glucoside AA2G powder is mild and stable, offering good compatibility with most ingredients; however, it should not be combined with the following: strong oxidizing agents (such as benzoyl peroxide), which can degrade its structure and cause inactivation; high concentrations of acids (such as AHAs or salicylic acid), as their optimal pH ranges conflict (separate morning and evening use is recommended); and retinol, as differing pH requirements suggest alternating use to avoid interference or increased irritation risk. Conversely, AA2G pairs excellently with niacinamide, creating a synergistic effect that brightens the complexion and fades dark spots; it is also suitable for use alongside gentle ingredients like hyaluronic acid and peptides.
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